Apigeninas: Skirtumas tarp puslapio versijų
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Eilutė 7:
Neseniai parodyta, kad Apigeninas sukelia autofagijos procesą, kuris aiškina jo chemioprevencines savybes, tačiau tuo pat metu stabdo dalies vaistų organizme įsisavinimą, <ref>{{cite journal | author = RR Ruela-de-Sousa, GM Fuhler, N Blom, CV Ferreira, H Aoyama, MP Peppelenbosch | title = Cytotoxicity of apigenin on leukemia cell lines: implications for prevention and therapy | journal = Cell Death and Disease| year = 2010 | volume = 1 | issue = e19 | pages = 1–11}}</ref>.Apigenin is a potent [[enzyme inhibitor|inhibitor]] of [[CYP2C9]],<ref name="Si_2009">{{cite journal | author = Si Dayong, Wang Y, Zhou Y-H, Guo Y, Wang J, Zhou H, Li Z-S, Fawcett JP | title = Mechanism of CYP2C9 inhibition by flavones and flavonols | journal = Drug Metabolism and Disposition | volume =37 | issue = | pages =629–634 | year = 2009 | month =March | pmid = | doi = 10.1124/dmd.108.023416 | url = http://p4502c.googlepages.com/dmd2.pdf | issn = }}</ref> an [[enzyme]] sąveikaudamas su vaistų apykaitą kūne skatinančiu fermentu.
Apigeninas sąveikauja su [[Cyclosporinu]] - vaistu slopinančiu imuniteto priešimimąsi organų persodinimo operacijose. Tirtas jo poveikis [[bcl-2]] ir ląstelių natūraliai mirčiai - [[Apoptozė|apoptozei]].<ref>{{cite journal | author = Srikumar Chakravarthi, Chong Fu Wen, HS Nagaraja | title = Apoptosis and expression of bcl-2 in cyclosporine induced renal damage and its reversal by beneficial effects of 4,5,7 - Trihydroxyflavone | journal = Journal of Analytical Bio Science | year = 2009 | volume = 32 | issue = 4 | pages = 320–327}}</ref> Vertintas transformuojančio augimo faktoriaus-β ir apoptozės indeksas sąveikoje su cyclosporinu A, jam pažeidus inkstus .<ref>{{cite journal | author = Chong FW, Srikumar Chakravarthi, HS Nagaraja, PM Thanikachalam, Nagarajah Lee | title = Expression of Transforming Growth factor-β and determination of Apoptotic Index in histopathological sections for assessment of the effects of Apigenin (4’,5’,7’- trihydroxyflavone) on Cyclosporine A induced renal damage | journal = Malaysian Journal of Pathology | year = 2009 | volume = 31 | issue = 1 | pages = 35–43}}</ref>
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